South Wairarapa Rebus Club
Rebus Club member, Dr David Woodhams, challenged the group’s August meeting to consider the ethical issues surrounding our developing capability of editing human genes.
Early genetic engineering involved the joining of DNA from different species and subsequently inserting the hybrid DNA into a host cell, often a bacterium.
A common example, dating from 1978, is the production of insulin by bacteria into which the human insulin gene has been inserted. Until then, a single gram of insulin for treatment of diabetes, equivalent to about 28,800 units, required its extraction from eight kilograms of pancreas glands taken from more than 50 slaughtered pigs or cows.
Another example, more controversial, is the development of crop plant varieties that are resistant to herbicide.
In 2002 the method which bacteria have evolved to make themselves immune to viral attack was discovered, known by the acronym CRISPR, and from this discovery scientists have learned to insert genetic material into human genes with convincing precision.
There are two forms of genetic editing.
One embraces treatment that influences the DNA only of the cells of an individual – the edit can’t be passed on to descendants – that’s somatic treatment.
The other, germline editing, specifically includes the ability to pass on the edit to succeeding generations. Therein lie the ethical challenges. … Continue Reading
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